Discussion:
Linolenic Limits Advanced Glycation End-products (AGEs)
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ironjustice
2016-11-19 16:45:50 UTC
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Linolenic acid prevents early and advanced glycation end-products (AGEs) modification of albumin.
Prasanna G1, Saraswathi NT2.
Int J Biol Macromol. 2016 Nov 11. pii: S0141-8130(16)32383-2. doi: 10.1016/j.ijbiomac.2016.11.035.
Abstract
In this study, we report the protective effects of linolenic acid towards the formation of early (HbA1c) and advanced glycation end-products (AGEs) based on fluorescence, circular dichroism, confocal microscopy and molecular interaction studies. Linolenic acid was found to be a potent inhibitor of AGEs formed by both glucose and fructose. The HbA1c (early glycation product) level was found to be reduced to 7.4% when compared to glycated control (8.4%). Similarly, linolenic acid also inhibited the methylglyoxal mediated AGEs formation. Circular dichroism spectroscopy studies suggested that the protective effect of linolenic acid for the helical structure of albumin. The molecular interaction studies showed that linolenic acid interacts with arginine residues of albumin with high affinity. Results suggested linolenic acid to be a potent antiglycation compound and also it could be a better lead compound for AGE inhibition.
Copyright © 2016 Elsevier B.V. All rights reserved.
KEYWORDS:
HbA(1)c; Linolenic acid; advanced glycation end-products
PMID: 27845223 DOI: 10.1016/j.ijbiomac.2016.11.035

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Taka
2016-11-19 16:51:35 UTC
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Post by ironjustice
Linolenic acid prevents early and advanced glycation end-products (AGEs) modification of albumin.
Prasanna G1, Saraswathi NT2.
Int J Biol Macromol. 2016 Nov 11. pii: S0141-8130(16)32383-2. doi: 10.1016/j.ijbiomac.2016.11.035.
Abstract
In this study, we report the protective effects of linolenic acid towards the formation of early (HbA1c) and advanced glycation end-products (AGEs) based on fluorescence, circular dichroism, confocal microscopy and molecular interaction studies. Linolenic acid was found to be a potent inhibitor of AGEs formed by both glucose and fructose. The HbA1c (early glycation product) level was found to be reduced to 7.4% when compared to glycated control (8.4%). Similarly, linolenic acid also inhibited the methylglyoxal mediated AGEs formation.
Well, that is VERY surprising...

Circular dichroism spectroscopy studies suggested that the protective effect of linolenic acid for the helical structure of albumin. The molecular interaction studies showed that linolenic acid interacts with arginine residues of albumin with high affinity. Results suggested linolenic acid to be a potent antiglycation compound and also it could be a better lead compound for AGE inhibition.
Post by ironjustice
Copyright © 2016 Elsevier B.V. All rights reserved.
HbA(1)c; Linolenic acid; advanced glycation end-products
PMID: 27845223 DOI: 10.1016/j.ijbiomac.2016.11.035
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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