Going grey early increases heart attack risk

[Mario Micro]

Can anybody be kind and find the abstract for me? I've looked on Pubmed but I couldn't find it.

Article here:
http://www.telegraph.co.uk/news/2017/04/08/going-grey-early-increases-heart-attack-risk/

[Mario Micro]

Post by Mario Micro
Can anybody be kind and find the abstract for me? I've looked on Pubmed but I couldn't find it.
http://www.telegraph.co.uk/news/2017/04/08/going-grey-early-increases-heart-attack-risk/

Never mind, it's not on Pubmed yet but the abstract is here:



Abstract: 760
The degree of hair graying in male gender as an independent risk factor for coronary artery disease, a prospective study
Authors:
AMR Elfaramawy1, IRINI Samuel1, REHAM Darweesh1, AHMED Shehata1, HEBA Farouk1, HOSSAM Kandil1, 1Cairo University, Kasr Al-Ainy Hospital-Faculty of Medicine, Department of Cardiology - Cairo - Egypt,

Topic(s):
Risk factors: others
Citation:
European Journal of Preventive Cardiology ( April 2017 ) 24 ( Supplement 1 ), 168
Background: Cardiovascular disease is a leading cause of death worldwide. Aging is an unavoidable coronary risk factor and is associated with dermatological signs that could be a marker for increase coronary risk. We tested the hypothesis that hair graying as a visible marker of aging is associated with risk of coronary artery disease independent of chronological age
Method: This prospective observation study included 545 adult males who underwent a multi-slice computed tomography coronary angiography (MSCT CA) for suspicion of coronary artery disease (CAD), patients were divided into different subgroups according to the percentage of gray/white hairs (Hair Whitening Score, HWS: 1-5) and to absence or presence of CAD
Results: CAD was prevalent in 80% of our studied population, (46.8 %) had three vessels disease with mean age of 53.2 ± 10.7 yrs. Hypertension, diabetes and dyslipidemia were more prevalent in CAD group (P=0.001, P=0.001, and P=0.003 respectively). Patients with CAD had statistically significant higher HWS (3 or more, predominately white hair), (32.1 % Vs 60.1 %, p < 0.001) and significant coronary artery calcification (<0.001). Multivariate regression analysis showed that age (OR: 2.40, 95% CI: [1.31-4.39], p= 0.004), Hair Whitening Score (OR: 1.31, 95% CI: [1.09-1.57], p= 0.004), hypertension (OR: 1.63, 95% CI: [1.03-2.58], p=0.036), and dyslipidemia (OR: 1.61, 95% CI: [1.02-2.54], p=0.038) were independent predictors of presence of atherosclerotic CAD and only age (p < 0.001) was found as independent predictor of hair graying.
Conclusion: In our population, high hair whitening score was associated with increased risk of CAD independent of chronological age and other established cardiovascular risk factors

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Post by Mario Micro
Conclusion: In our population, high hair whitening score was associated with increased risk of CAD independent of chronological age and other established cardiovascular risk factors

Psychological stress is associated with hair greying and oxidative stress is associated with balding.
"We examined premature graying in young dogs age 1–4 years.•Photographs of dogs were compared to owner report questionnaire responses.•Impulsivity behaviors were significantly associated with premature graying.•Anxiety behaviors were significantly associated with premature graying.•Fear of noise, unfamiliar animals & people were significant for premature graying."

King, C., Smith, T. J., Grandin, T., & Borchelt, P. (2016). Anxiety and impulsivity: Factors associated with premature graying in young dogs. Applied Animal Behaviour Science, 18578-85. doi:10.1016/j.applanim.2016.09.013

"The concept of measuring aging biologically rather than only chronologically may be of importance in clinical practice. Hair graying is the most apparent sign of biological aging in humans... In our study, we found that the degree of gray/white hairs is related to extent of CAD. Our findings also suggested that hair graying is a risk marker for CAD"

Kocaman, S. A., Çetin, M., Durakoğ;lugil, M. E., Turan, E., Çanga, A., Çiçek, Y., & ... Bostan, M. (2012). The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age. Anatolian Journal Of Cardiology / Anadolu Kardiyoloji Dergisi, 12(6), 457-463. doi:10.5152/akd.2012.150

"Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs. These in vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors."

Upton, J. H., Hannen, R. F., Bahta, A. W., Farjo, N., Farjo, B., & Philpott, M. P. (2015). Original Article: Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia. Journal Of Investigative Dermatology, 1351244-1252. doi:10.1038/jid.2015.28