Phospholipids In Severe Infections

ironjustice

2016-08-09 15:31:08 UTC

Therapeutic efficacy of lysophosphatidylcholine in severe infections caused by Acinetobacter baumannii.
Smani Y1, Domínguez-Herrera J2, Ibáñez-Martínez J3, Pachón J2.
Antimicrob Agents Chemother. 2015 Jul;59(7):3920-4. doi: 10.1128/AAC.04986-14. Epub 2015 Apr 20.
1Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain ***@hotmail.com.
2Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.
3Department of Pathology, University Hospital Virgen Macarena, Seville, Spain.

Abstract

Due to the significant increase in antimicrobial resistance of Acinetobacter baumannii, immune system stimulation to block infection progression may be a therapeutic adjuvant to antimicrobial treatment. Lysophosphatidylcholine (LPC), a major component of phospholipids in eukaryotic cells, is involved in immune cell recruitment and modulation. The aim of this study was to show if LPC could be useful for treating infections caused by A. baumannii. A. baumannii ATCC 17978 was used in this study. Levels of serum LPC and levels of the inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), IL-1β, and IL-10 were determined by spectrophotometric assay and enzyme-linked immunosorbent assay (ELISA), respectively, using a murine peritoneal sepsis model in which mice were inoculated with 5.3 log CFU/ml of A. baumannii. The therapeutic efficacy of LPC against A. baumannii in murine peritoneal sepsis and pneumonia models was assessed for 48 h after bacterial infection. At early time points in the murine model of peritoneal sepsis caused by A. baumannii, LPC was depleted and was associated with an increase of inflammatory cytokine release. Preemptive therapy with LPC in murine peritoneal sepsis and pneumonia models markedly enhanced spleen and lung bacterial clearance and reduced the numbers of positive blood cultures and the mouse mortality rates. Moreover, treatment with LPC reduced proinflammatory cytokine production. These data demonstrate that LPC is efficacious as a preemptive treatment in experimental models of peritoneal sepsis and pneumonia caused by A. baumannii.

Copyright © 2015, American Society for Microbiology. All Rights Reserved.

PMID: 25896698 PMCID: PMC4468695 DOI: 10.1128/AAC.04986-14

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Bacterial Inhibition of Phosphatidylcholine Synthesis Triggers
Apoptosis in the Brain

"Supplementation with lyso-phosphatidylcholine prevents cell death"

Supplementation with exogenous lyso-phosphatidylcholine
prevents cell death and treatment of mice with cytidine
diphosphocholine attenuates hippocampal damage during
meningitis, even after the onset of infection.
We conclude that bacterial inhibition of PtdCho biosynthesis
activates an apoptotic cascade that is a causative event in
pathogenesis and amenable to therapeutic intervention.

http://jem.rupress.org/cgi/content/full/200/1/99

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"Results suggest lysophosphatidylcholine can prevent and treat
sepsis and microbial infections"

Therapeutic effects of lysophosphatidylcholine in experimental sepsis

http://www.ncbi.nlm.nih.gov/pubmed/14716308

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"Phospholipids are degraded to lyso-phosphatidylcholine in the intestine and absorbed primarily in this form."

http://www.heilpflanzen-welt.de/1994-07-Soy-Phospholipid-Phospholipide-aus-Sojabohnen-mit-73-79-3-sn-Phosphatidyl-cholin/

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